Having viewed the third film in the series, my opinion is the film is an asset to the series and moved the story of Alice well.
The role of Claire is a great substitute for the missing Jill, and the convoy part was not only a nod to Mad Max but to the Hitchcock classic "The birds," which was a good dose of chills to add.
I have to add that much to my pleasure Ali Larter in the role of Claire was not eye-candy as I suspected. After the S.T.A.R.S. agent in 1 and Jill in 2 it would have been a mistake to have a lady in for eye-candy in my opinion.
Science goes so far and then the developments are mutated as seen at the end.